Targets for Current Pharmacologic Therapy in Cholesterol Gallstone Disease
نویسندگان
چکیده
منابع مشابه
Hepatic cholesterol metabolism in cholesterol gallstone disease.
Hepatic cholesterol metabolism was examined in 27 Swedish patients with cholesterol gallstone disease and in 13 patients free of gallstones operated for roentgenographically suspect polyps in the gallbladder. All 40 patients underwent cholecystectomy, and a liver biopsy and gallbladder bile were obtained at surgery. The cholesterol saturation of gallbladder bile was significantly higher in pati...
متن کاملCholesterol gallstone disease.
With a prevalence of 10-15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West. The interplay between interprandial and postprandial physiological responses to endogenous and dietary lipids underscores the importance of coordinated hepatobiliary and gastrointestinal functions to prevent crystallisation and precipitation of...
متن کاملCurrent Views on Genetics and Epigenetics of Cholesterol Gallstone Disease
Cholesterol gallstone disease, one of the commonest digestive diseases in western countries, is induced by an imbalance in cholesterol metabolism, which involves intestinal absorption, hepatic biosynthesis, and biliary output of cholesterol, and its conversion to bile acids. Several components of the metabolic syndrome (e.g., obesity, type 2 diabetes, dyslipidemia, and hyperinsulinemia) are als...
متن کاملGenetic factors in cholesterol gallstone disease
Most common diseases are strongly influenced by inheritance, but, to date, relatively few genes have been identified that are responsible for the familial clustering of these diseases. In the great majority of cases, no Mendelian inherited trait can be demonstrated. With the exception of cholesterol gallstones associated with low phospholipid level, induced by mutations in the gene of the multi...
متن کاملGenetic predisposition of cholesterol gallstone disease.
Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors implicated in different metabolic pathways. However...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology Clinics of North America
سال: 2010
ISSN: 0889-8553
DOI: 10.1016/j.gtc.2010.02.005